Oxidation of specific methionine and tryptophan residues of apolipoprotein A-I in hepatocarcinogenesis
Fernández-Irigoyen, Jokin Santamaría, Enrique Sesma, Laura Muñoz, Javier Riezu, José Ignacio Caballería, Juan Lu, Shelly C. Prieto, Jesús Mato, José M. Avila, Matías a Corrales, Fernando J.
Proteomics, 2005
https://doi.org/10.1002/pmic.200500070
 
 
ORCID: 0000-0001-5072-4099
Proteomic Analysis of Liver Diseases: Molecular Mechanisms and Biomarker Discovery 10.2174/138955708783331595
Proteomic atlas of the human olfactory bulb 10.1016/j.jprot.2012.05.011
Mass spectrometric characterization of mitochondrial complex I NDUFA10 variants 10.1002/pmic.200701085
Anthracene drives sub-cellular proteome-wide alterations in the degradative system of Penicillium oxalicum https://doi.org/10.1016/j.ecoenv.2018.04.051
Aldosterone Impairs Mitochondrial Function in Human Cardiac Fibroblasts via A-Kinase Anchor Protein 12 10.1038/s41598-018-25068-6
Oncolytic adenovirus Delta-24-RGD induces a widespread glioma proteotype remodeling during autophagy. 10.1016/j.jprot.2018.11.020
Unveiling the olfactory proteostatic disarrangement in Parkinson's disease by proteome-wide profiling. 10.1016/j.neurobiolaging.2018.09.018
Spatial and temporal proteome dynamics of glioma cells during oncolytic adenovirus Delta-24-RGD infection. 10.18632/oncotarget.25774
Galectin-3 down-regulates antioxidant peroxiredoxin-4 in human cardiac fibroblasts: a new pathway to induce cardiac damage. 10.1042/cs20171389
A role for fumarate hydratase in mediating oxidative effects of galectin-3 in human cardiac fibroblasts. 10.1016/j.ijcard.2017.12.103
MicroRNA-506 promotes primary biliary cholangitis-like features in cholangiocytes and immune activation. 10.1002/hep.29533
Mass Spectrometry-Based Proteomic Profiling of Thrombotic Material Obtained by Endovascular Thrombectomy in Patients with Ischemic Stroke. 10.3390/ijms19020498
Characterization of Macrophage Endogenous S-Nitrosoproteome Using a Cysteine-Specific Phosphonate Adaptable Tag in Combination with TiO2 Chromatography. 10.1021/acs.jproteome.7b00812
Network-Driven Proteogenomics Unveils an Aging-Related Imbalance in the Olfactory IκBα-NFκB p65 Complex Functionality in Tg2576 Alzheimer's Disease Mouse Model. 10.3390/ijms18112260
Differential Proteomics Identifies Reticulocalbin-3 as a Novel Negative Mediator of Collagen Production in Human Cardiac Fibroblasts. 10.1038/s41598-017-12305-7
Olfactory bulb neuroproteomics reveals a chronological perturbation of survival routes and a disruption of prohibitin complex during Alzheimer's disease progression. 10.1038/s41598-017-09481-x
Differential proteomics reveals S100-A11 as a key factor in aldosterone-induced collagen expression in human cardiac fibroblasts. 10.1016/j.jprot.2017.07.011
Progressive modulation of the human olfactory bulb transcriptome during Alzheimer´s disease evolution: novel insights into the olfactory signaling across proteinopathies. 10.18632/oncotarget.18193
A multicentric study to evaluate the use of relative retention times in targeted proteomics. 10.1016/j.jprot.2016.10.014
An early dysregulation of FAK and MEK/ERK signaling pathways precedes the β-amyloid deposition in the olfactory bulb of APP/PS1 mouse model of Alzheimer's disease. 10.1016/j.jprot.2016.07.032
Deconstructing the molecular architecture of olfactory areas using proteomics. 10.1002/prca.201500147
Quantitative proteomics reveals the importance of nitrogen source to control glucosinolate metabolism in Arabidopsis thaliana and Brassica oleracea. 10.1093/jxb/erw147
Drafting the proteome landscape of myeloid-derived suppressor cells. 10.1002/pmic.201500229
Olfactory bulb proteome dynamics during the progression of sporadic Alzheimer's disease: identification of common and distinct olfactory targets across Alzheimer-related co-pathologies. 10.18632/oncotarget.6254
A core of kinase-regulated interactomes defines the neoplastic MDSC lineage. 10.18632/oncotarget.4746
New insights into the human brain proteome: Protein expression profiling of deep brain stimulation target areas. 10.1016/j.jprot.2015.03.032
Toward defining the anatomo-proteomic puzzle of the human brain: An integrative analysis. 10.1002/prca.201400127
Anatomo-proteomic characterization of human basal ganglia: focus on striatum and globus pallidus. 10.1186/s13041-014-0083-9
A highly efficient tumor-infiltrating MDSC differentiation system for discovery of anti-neoplastic targets, which circumvents the need for tumor establishment in mice. 10.18632/oncotarget.2279
Applying mass spectrometry-based qualitative proteomics to human amygdaloid complex. 10.3389/fncel.2014.00080
Contribution of MS-Based Proteomics to the Understanding of Herpes Simplex Virus Type 1 Interaction with Host Cells. 10.3389/fmicb.2012.00107
Proteomic analysis of human hepatoma cells expressing methionine adenosyltransferase I/III: Characterization of DDX3X as a target of S-adenosylmethionine. 10.1016/j.jprot.2012.01.009
A combination of affinity chromatography, 2D DIGE, and mass spectrometry to analyze the phosphoproteome of liver progenitor cells. 10.1007/978-1-61779-959-4_12
Enzymatic activity of methionine adenosyltransferase variants identified in patients with persistent hypermethioninemia. 10.1016/j.ymgme.2010.07.009
Regulation of stathmin phosphorylation in mouse liver progenitor-29 cells during proteasome inhibition. 10.1002/pmic.200900110
Identification of replication-competent HSV-1 Cgal+ strain targets in a mouse model of human hepatocarcinoma xenograft. 10.1016/j.jprot.2009.06.008
Identification of replication-competent HSV-1 Cgal+ strain signaling targets in human hepatoma cells by functional organelle proteomics. 10.1074/mcp.M800202-MCP200
Redox regulation of methylthioadenosine phosphorylase in liver cells: molecular mechanism and functional implications. 10.1042/bj20071569
Toward the discovery of new biomarkers of hepatocellular carcinoma by proteomics. 10.1111/j.1478-3231.2007.01447.x
Molecular profiling of hepatocellular carcinoma in mice with a chronic deficiency of hepatic s-adenosylmethionine: relevance in human liver diseases. 10.1021/pr050429v
Application of Isobaric Tags for Relative and Absolute Quantitation (iTRAQ) to Monitor Olfactory Proteomes During Alzheimer's Disease Progression 10.1007/978-1-4939-7119-0_3
Brain Proteomics: Decoding Neuroproteomes Using Mass Spectrometry 10.1007/978-1-4939-7119-0_1
Fiber-Optic Immunosensor Based on an Etched SMS Structure 10.1109/JSTQE.2016.2633819
Methods for Human Olfactory Bulb Tissue Studies Using Peptide/Protein MALDI-TOF Imaging Mass Spectrometry (MALDI-IMS) 10.1007/978-1-4939-7119-0_7
Proteomic Analysis of Extracellular Vesicles in Neurological Diseases 10.1007/978-1-4939-7119-0_15
Oxidation of specific methionine and tryptophan residues of apolipoprotein A-I in hepatocarcinogenesis 10.1002/pmic.200500070
Methylthioadenosine phosphorylase gene expression is impaired in human liver cirrhosis and hepatocarcinoma 10.1016/j.bbadis.2004.08.002
Influence of short‐term training on functional capacity and (anti‐)inflammatory immune signalling in acute hospitalization 10.1002/jcsm.12582
Profound Reprogramming towards Stemness in Pancreatic Cancer Cells as Adaptation to AKT Inhibition 10.3390/cancers12082181
Soluble St2 Induces Cardiac Fibroblast Activation and Collagen Synthesis via Neuropilin-1 10.3390/cells9071667
Absence of Nuclear p16 Is a Diagnostic and Independent Prognostic Biomarker in Squamous Cell Carcinoma of the Cervix 10.3390/ijms21062125
N-terminal acetylation mutants affect alpha-synuclein stability, protein levels and neuronal toxicity 10.1016/j.nbd.2020.104781
Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy 10.1007/s00401-019-02122-9
Fiber-based early diagnosis of venous thromboembolic disease by label-free D-dimer detection 10.1016/j.biosx.2019.100026
Amyotrophic Lateral Sclerosis Is Accompanied by Protein Derangements in the Olfactory Bulb-Tract Axis 10.3390/ijms21218311
Cannabis Use Induces Distinctive Proteomic Alterations in Olfactory Neuroepithelial Cells of Schizophrenia Patients 10.3390/jpm11030160
Understanding the Molecular Mechanism of miR-877-3p Could Provide Potential Biomarkers and Therapeutic Targets in Squamous Cell Carcinoma of the Cervix 10.3390/cancers13071739
Alteration in the Cerebrospinal Fluid Lipidome in Parkinson’s Disease: A Post-Mortem Pilot Study 10.3390/biomedicines9050491
Olfactory Bulb Proteomics Reveals Widespread Proteostatic Disturbances in Mixed Dementia and Guides for Potential Serum Biomarkers to Discriminate Alzheimer Disease and Mixed Dementia Phenotypes 10.3390/jpm11060503
Dysregulated protein phosphorylation: A determining condition in the continuum of brain aging and Alzheimer's disease 10.1111/bpa.12996
José Mato
Mato José
ORCID: 0000-0003-1264-3153
Crystallography captures catalytic steps in human methionine adenosyltransferase enzymes 10.1073/pnas.1510959113
Deregulated Methionine Adenosyltransferase alpha 1, c-Myc, and Maf Proteins Together Promote Cholangiocarcinoma Growth in Mice and Humans 10.1002/hep.28541
Liver receptor homolog 1 and transmethylation fluxes in nonalcoholic steatohepatitis 10.1002/hep.28146
Metabolic Characterization of Advanced Liver Fibrosis in HCV Patients as Studied by Serum H-1-NMR Spectroscopy 10.1371/journal.pone.0155094
Metabolomics as a diagnostic tool for idiopathic non-cirrhotic portal hypertension 10.1111/liv.12972
Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis 10.1016/j.jhep.2015.08.037
Activation of a Novel c-Myc-miR27-Prohibitin 1 Circuitry in Cholestatic Liver Injury Inhibits Glutathione Synthesis in Mice 10.1089/ars.2014.6027
Enhancing metabolomics research through data mining 10.1016/j.jprot.2015.01.019
Integrative Genomic Signatures Of Hepatocellular Carcinoma Derived from Nonalcoholic Fatty Liver Disease 10.1371/journal.pone.0124544
Methionine Adenosyltransferase 2B-GIT1 Complex Serves as a Scaffold to Regulate Ras/Raf/MEK1/2 Activity in Human Liver and Colon Cancer Cells 10.1016/j.ajpath.2014.12.016
S-adenosylmethionine and methylthioadenosine inhibit β-catenin signaling by multiple mechanisms in liver and colon cancers 10.1124/mol.114.095679
S-Adenosylmethionine increases circulating very-low density lipoprotein clearance in non-alcoholic fatty liver disease 10.1016/j.jhep.2014.10.019
Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves 10.1083/jcb.201503019
TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency 10.1038/labinvest.2014.151
Glycine N-methyltransferase expression in the hippocampus and its role in neurogenesis and cognitive performance 10.1002/hipo.22274
Methionine adenosyltransferase 2B, HuR, and sirtuin 1 protein cross-talk impacts on the effect of resveratrol on apoptosis and growth in liver cancer cells (vol 288, pg 23161, 2013) 10.1074/jbc.A113.487157
Quantitative proteomic analysis of hepatocyte-secreted extracellular vesicles reveals candidate markers for liver toxicity 10.1016/j.jprot.2014.04.008
S-adenosylmethionine Levels Regulate the Schwann Cell DNA Methylome 10.1016/j.neuron.2014.01.037
SIRT1 Controls Liver Regeneration by Regulating Bile Acid Metabolism Through Farnesoid X Receptor and Mammalian Target of Rapamycin Signaling 10.1002/hep.26971
Structure and function study of the complex that synthesizes S-adenosylmethionine 10.1107/S2052252514012585
Surfing Transcriptomic Landscapes. A Step beyond the Annotation of Chromosome 16 Proteome 10.1021/pr400721r
Systems Biology for Hepatologists 10.1002/hep.27023
A DNA methylation signature associated with the epigenetic repression of glycine N-methyltransferase in human hepatocellular carcinoma 10.1007/s00109-013-1010-8
A fast method for the quantitation of key metabolites of the methionine pathway in liver tissue by high-resolution mass spectrometry and hydrophilic interaction ultra-performance liquid chromatography 10.1007/s00216-013-6883-4
A metabolic signature predicts biological age in mice 10.1111/acel.12025
Excess S-adenosylmethionine Reroutes Phosphatidylethanolamine Towards Phosphatidylcholine and Triglyceride Synthesis 10.1002/hep.26399
MAT2B-GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer 10.1002/hep.26258
Metabolomics Discloses Potential Biomarkers for the Noninvasive Diagnosis of Idiopathic Portal Hypertension 10.1038/ajg.2013.11
Methionine Adenosyltransferase 2B, HuR, and Sirtuin 1 Protein Cross-talk Impacts on the Effect of Resveratrol on Apoptosis and Growth in Liver Cancer Cells 10.1074/jbc.M113.487157
MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma 10.1172/JCI63861
Non-invasive detection of drug toxicity in rats by solid-phase extraction and MALDI-TOF analysis of urine samples 10.1007/s00216-012-6644-9
Polyamine and methionine adenosyltransferase 2A crosstalk in human colon and liver cancer 10.1016/j.yexcr.2013.04.005
Solute Carrier Family 2 Member 1 Is Involved in the Development of Nonalcoholic Fatty Liver Disease 10.1002/hep.26052
Spanish Human Proteome Project: Dissection of Chromosome 16 10.1021/pr300898u
Assays for methionine γ-lyase and S-adenosyl-l-homocysteine hydrolase based on enzymatic formation of CdS quantum dots in situ 10.1021/ac302770q
Effects of S-adenosylmethionine and methylthioadenosine on inflammation-induced colon cancer in mice 10.1093/carcin/bgr295
Hepatoma Cells From Mice Deficient in Glycine N-Methyltransferase Have Increased RAS Signaling and Activation of Liver Kinase B1 10.1053/j.gastro.2012.05.050
Human antigen R contributes to hepatic stellate cell activation and liver fibrosis 10.1002/hep.25828
Inhibition of human methionine adenosyltransferase 1A transcription by coding region methylation 10.1002/jcp.22875
Inhibition of natural killer cells protects the liver against acute injury in the absence of glycine N-methyltransferase 10.1002/hep.25694
Magnetic superspace groups and symmetry constraints in incommensurate magnetic phases 10.1088/0953-8984/24/16/163201
Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis 10.1016/j.jhep.2012.05.024
Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation 10.1002/hep.24795
Obesity-Dependent Metabolic Signatures Associated with Nonalcoholic Fatty Liver Disease Progression 10.1021/pr201223p
Proteomic analysis of human hepatoma cells expressing methionine adenosyltransferase I/III Characterization of DDX3X as a target of S-adenosylmethionine 10.1016/j.jprot.2012.01.009
S-adenosyl methionine regulates ubiquitin-conjugating enzyme 9 protein expression and sumoylation in murine liver and human cancers 10.1002/hep.25701
S-ADENOSYLMETHIONINE IN LIVER HEALTH, INJURY, AND CANCER 10.1152/physrev.00047.2011
Serum UPLC-MS/MS metabolic profiling in an experimental model for acute-liver injury reveals potential biomarkers for hepatotoxicity 10.1007/s11306-011-0329-9
The RNA-Binding Protein Human Antigen R Controls Global Changes in Gene Expression during Schwann Cell Development 10.1523/JNEUROSCI.5868-11.2012
A HUNDRED YEARS OF VITAMINS 10.3989/arbor.2011.extran1118
A signature of six genes highlights defects on cell growth and specific metabolic pathways in murine and human hepatocellular carcinoma 10.1007/s10142-011-0230-7
HIGH-FREQUENCY ULTRASOUND IMAGING FOR LONGITUDINAL EVALUATION OF NON-ALCOHOLIC FATTY LIVER DISEASE PROGRESSION IN MICE 10.1016/j.ultrasmedbio.2011.04.012
Insulin-like growth factor 1 activates methionine adenosyltransferase 2A transcription by multiple pathways in human colon cancer cells 10.1042/BJ20101754
Methionine Adenosyltransferase 1A Gene Deletion Disrupts Hepatic Very Low-Density Lipoprotein Assembly in Mice 10.1002/hep.24607
Role of AMP-activated protein kinase in the control of hepatocyte priming and proliferation during liver regeneration 10.1258/ebm.2011.010352
The Hepatocarcinogenic Effect of Methionine and Choline Deficient Diets: An Adaptation to the Warburg Effect? 10.1111/j.1530-0277.2010.01404.x
Where Are We in the Search for Noninvasive Nonalcoholic Steatohepatitis Biomarkers? 10.1002/hep.24642
Activation of LKB1-Akt Pathway Independent of Phosphoinositide 3-Kinase Plays a Critical Role in the Proliferation of Hepatocellular Carcinoma from Nonalcoholic Steatohepatitis 10.1002/hep.23860
Altered hepatic lipid and apoB homeostasis is related to ER-stress gene downregulation leading to caspase-12 inhibition during NAFLD in MAT1A-KO mice 10.1016/j.chemphyslip.2010.05.183
Fatty Liver and Fibrosis in Glycine N-Methyltransferase Knockout Mice Is Prevented by Nicotinamide 10.1002/hep.23639
Forced Expression of Methionine Adenosyltransferase 1A in Human Hepatoma Cells Suppresses in Vivo Tumorigenicity in Mice 10.2353/ajpath.2010.090810
Hepatic Expression Patterns of Inflammatory and Immune Response Genes Associated with Obesity and NASH in Morbidly Obese Patients 10.1371/journal.pone.0013577
Impaired VLDL secretion and metabolism are related to non-alcoholic steatohepatitis in glycine N-methyltransferase deficient mice 10.1016/j.chemphyslip.2010.05.194
Liquid Chromatography-Mass Spectrometry-Based Parallel Metabolic Profiling of Human and Mouse Model Serum Reveals Putative Biomarkers Associated with the Progression of Nonalcoholic Fatty Liver Disease 10.1021/pr1002593
Liver-Specific Deletion of Prohibitin 1 Results in Spontaneous Liver Injury, Fibrosis, and Hepatocellular Carcinoma in Mice 10.1002/hep.23919
Novel function and intracellular localization of methionine adenosyltransferase 2β splicing variants 10.1074/jbc.M109.094821
Overview of extracellular microvesicles in drug metabolism 10.1517/17425251003614766
S-Adenosylmethionine Regulates Dual-Specificity Mitogen-Activated Protein Kinase Phosphatase Expression in Mouse and Human Hepatocytes 10.1002/hep.23530
Sirtuin 1 regulation of developmental genes during differentiation of stem cells 10.1073/pnas.1001399107
Sub-proteome approach to the knowledge of liver 10.1002/prca.200900123
Hepatocellular carcinoma in GNMT-/- mice 10.1016/j.taap.2009.03.017
Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes 10.1021/pr8004887
Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory β subunit and quinolone-based compounds 10.1111/febs.14790
Fine-Tuning of Sirtuin 1 Expression Is Essential to Protect the Liver From Cholestatic Liver Disease 10.1002/hep.30275
Metabolomics discloses potential biomarkers to predict the acute HVPG response to propranolol in patients with cirrhosis 10.1111/liv.14042
The mitochondrial chaperone Prohibitin 1 negatively regulates interleukin-8 in human liver cancers 10.1074/jbc.RA118.004863
Liver cancer-associated changes to the proteome: what deserves clinical focus? 10.1080/14789450.2018.1521277
Metabolomic-Based Noninvasive Serum Test to Diagnose Nonalcoholic Steatohepatitis: Results From Discovery and Validation Cohorts 10.1002/hep4.1188
Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy 10.1177/1535370217740860
MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis 10.1038/s41419-018-1014-y
Obeticholic Acid Modulates Serum Metabolites and Gene Signatures Characteristic of Human NASH and Attenuates Inflammation and Fibrosis Progression in Ldlr-/-.Leiden Mice 10.1002/hep4.1270
Prohibitin 1 Acts As a Negative Regulator of Wingless/Integrated-Beta-Catenin Signaling in Murine Liver and Human Liver Cancer Cells 10.1002/hep4.1257
Repurposing ciclopirox as a pharmacological chaperone in a model of congenital erythropoietic porphyria 10.1126/scitranslmed.aat7467
SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer 10.1016/j.ebiom.2018.12.031
Use of a metabolomic approach to non-invasively diagnose non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus 10.1111/dom.13285
A Metabolomics Signature Linked To Liver Fibrosis In The Serum Of Transplanted Hepatitis C Patients 10.1038/s41598-017-10807-y
A morphological method for ammonia detection in liver 10.1371/journal.pone.0173914
Aramchol reduces established fibrosis in MCD diet animal model 10.1016/S0168-8278(17)31232-1
Comprehensive NAFLD diagnosis based on a noninvasive metabolomic approach in a liquid biopsy 10.1016/S0168-8278(17)31810-X
Deregulated Neddylation in Liver Fibrosis 10.1002/hep.28933/suppinfo
Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis 10.1053/j.gastro.2017.01.015
mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer 10.1038/nature22964
Noninvasive serum biomarkers reflect the effect of Aramchol on mice fibrotic livers 10.1016/S0168-8278(17)31628-8
Prioritizing Popular Proteins in Liver Cancer: Remodelling One-Carbon Metabolism 10.1021/acs.jproteome.7b00390
Prohibitin 1 Suppresses Liver Cancer Tumorigenesis in Mice and Human Hepatocellular and Cholangiocarcinoma Cells 10.1002/hep.28964
Role of Aramchol in Steatohepatitis and Fibrosis in Mice 10.1002/hep4.1107
The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury 10.1038/s41467-017-01970-x
ACID SPHINGOMYELINASE TARGETING REDUCES THE PROGRESSION OF DIET-INDUCED NON-ALCOHOLIC STEATOHEPATITIS IN MICE WITH DISRUPTED METHIONINE HOMEOSTASIS 10.1016/S0168-8278(16)01278-2
ALTERED LIVER REGENERATION AFTER PARTIAL HEPATECTOMY IN PML-KNOCKOUT MICE 10.1016/S0168-8278(16)01714-1
IDENTIFICATION OF LIPIDOMIC SIGNATURES THAT DEFINE THREE SPECIFIC SUBTYPES OF NAFLD AND DIFFERENTIATE NASH FROM SIMPLE STEATOSIS 10.1016/S0168-8278(16)01683-4
LKB1 ACTIVATES RAS PATHWAY IN HEPATOCELLULAR CARCINOMA BY TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF RASGRP3 10.1016/S0168-8278(16)01660-3
MCJ/DNAJC15, THE MITOCHONDRIAL FOE IN LIVER INJURY 10.1016/S0168-8278(16)00230-0
MicroRNA-mediated regulation of glutathione and methionine metabolism and its relevance for liver disease 10.1016/j.freeradbiomed.2016.03.021
MIR-873 PROMOTES LIVER DE-DIFFERENTIATION AND FIBROSIS TARGETING GLYCINE-N-METHYL TRANSFERASE 10.1016/S0168-8278(16)01718-9
Prohibitin 1 Regulates the H19-Igf2 Axis and Proliferation in Hepatocytes 10.1074/jbc.M116.744045
TARGETING OF MIR-518D REDUCES CHEMORESISTANCE IN HEPATOCELLULAR CARCINOMA CELL LINES 10.1016/S0168-8278(16)01014-X
S-adenosylmethionine 10.1081/E-EDS-120022079
One-Carbon Metabolism in Liver Health and Disease 10.1016/B978-0-12-804274-8.00054-0
Nanolcoholic fatty liver disease 10.4155/EBO.13.392
Role of S-Adenosyl-L-Methionine in alcohol-associated liver cancer 10.1159/000095071
S-Adenosylmethionine Regulates Cytoplasmic HuR Via AMP-Activated Kinase 10.1053/j.gastro.2006.04.019
5′-Methylthioadenosine Modulates the Inflammatory Response to Endotoxin in Mice and in Rat Hepatocytes 10.1002/hep.20154
Methionine adenosyltransferase α2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells 10.18632/oncotarget.5342
Purification, crystallization and preliminary crystallographic analysis of protein MJ1225 from Methanocaldococcus jannaschii, a putative archaeal homologue of-AMPK 10.1107/S1744309109026475
S-adenosylmethione and its metabolite induce apoptosis in HepG2 cells: Role of protein phosphatase 1 and Bcl-xS 10.1002/hep.20274
A Glycine N-methyltransferase knockout mouse model for humans with deficiency of this enzyme 10.1007/s11248-006-0008-1
Methionine Adenosyltransferase α1 Is Targeted to the Mitochondrial Matrix and Interacts with Cytochrome P450 2E1 to Lower Its Expression 10.1002/hep.30762
Report of the 9th HLPP Workshop October 2007, Seoul, Korea 10.1002/pmic.200800432
Homocysteine, the bad thiol 10.1002/hep.20708
Changes in the Expression of Methionine Adenosyltransferase Genes and S-Adenosylmethionine Homeostasis during Hepatic Stellate Cell Activation 10.1002/hep.23411
Methylthioadenosine 10.1016/j.biocel.2003.11.016
The 2006 human liver proteome project (HLPP) workshops 10.1002/prca.200700242
Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer 10.1053/j.gastro.2018.04.032
Molecular profiling of hepatocellular carcinoma in mice with a chronic deficiency of hepatic S-adenosylmethionine: Relevance in human liver diseases 10.1021/pr050429v
Transcription of the MAT2A gene, coding for methionine adenosyltransferase, is up-regulated by E2F and Sp1 at a chromatin level during proliferation of liver cells 10.1016/j.biocel.2007.01.009
Functional proteomics of nonalcoholic steatohepatitis: Mitochondrial proteins as targets of S-adenosylmethionine 10.1073/pnas.0536625100
Methionine adenosyltransferase II β subunit gene expression provides a proliferative advantage in human hepatoma 10.1053/gast.2003.50151
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice 10.1002/hep.22159
Effect of hepatocyte growth factor on methionine adenosyltransferase genes and growth is cell density-dependent in HepG2 cells 10.1002/jcp.20891
Folding of dimeric methionine adenosyltransferase III: Identification of two folding intermediates 10.1074/jbc.M111546200
Inhibition of human betaine-homocysteine methyltransferase expression by S-adenosylmethionine and methylthioadenosine 10.1042/BJ20061119
Deregulated neddylation in liver fibrosis 10.1002/hep.28933
Pancreatic cancer escape variants that evade immunogene therapy through loss of sensitivity to IFNγ-induced apoptosis 10.1038/sj.gt.3301957
miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease 10.1016/j.molmet.2019.08.008
Correlation between gene expression and GO semantic similarity 10.1109/TCBB.2005.50
Id2 leaves the chromatin of the E2F4-p130-controlled c-myc promoter during hepatocyte priming for liver regeneration 10.1042/BJ20060380
Genetic polymorphisms in the Methylenetetrahydrofolate reductase and Thymidylate synthase genes and risk of hepatocellular carcinoma 10.1002/hep.21735
L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells. Role of S-adenosylmethionine 10.1074/jbc.M211554200
Altered liver gene expression in CCl4-cirrhotic rats is partially normalized by insulin-like growth factor-I 10.1016/S1357-2725(01)00123-6
Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1 10.1002/hep.27959
Role of abnormal methionine metabolism in alcoholic liver injury 10.1016/S0741-8329(02)00226-4
Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice 10.1002/hep.22141
Evidence for LKB1/AMP-activated protein kinase/endothelial nitric oxide synthase cascade regulated by hepatocyte growth factor, S-adenosylmethionine, and nitric oxide in hepatocyte proliferation 10.1002/hep.22660
S-Adenosylmethionine in cell growth, apoptosis and liver cancer 10.1111/j.1440-1746.2007.05289.x
The role of stem cells/progenitor cells in liver carcinogenesis in glycine N-methyltransferase deficient mice 10.1016/j.yexmp.2010.01.004
Acid sphingomyelinase-ceramide system in steatohepatitis: A novel target regulating multiple pathways 10.1016/j.jhep.2014.09.023
The 2011 Human Liver Proteome Project (HLPP) Workshop September 5, 2011, Geneva, Switzerland. 10.1002/pmic.201100555
Non-alcoholic steatohepatitis and animal models: Understanding the human disease 10.1016/j.biocel.2008.10.027
Expression of Wilms' tumor suppressor in the liver with cirrhosis: Relation to hepatocyte nuclear factor 4 and hepatocellular function 10.1053/jhep.2003.50269
Changes in S-adenosylmethionine and GSH homeostasis during endotoxemia in mice 10.1038/labinvest.2008.69
Nonalcoholic fatty liver disease: Update on pathogenesis, diagnosis, treatment and the role of S-adenosylmethionine 10.1177/1535370215579161
Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect 10.1038/onc.2008.436
S-adenosylmethionine: A control switch that regulates liver function 10.1096/fj.01-0401rev
S-adenosylmethionine and proliferation: New pathways, new targets 10.1042/BST0360848
Methionine adenosyltransferase and S-adenosylmethionine in alcoholic liver disease 10.1111/j.1440-1746.2006.04575.x
Crystallization and preliminary crystallographic analysis of merohedrally twinned crystals of MJ0729, a CBS-domain protein from Methanococcus jannaschii 10.1107/S1744309108013432
GARBAN: Genomic analysis and rapid biological annotation of cDNA microarray and proteomic data 10.1093/bioinformatics/btg291
Influence of impaired liver methionine metabolism on the development of vascular disease and inflammation 10.2174/1568016054368197
Inhibition of lipopolysaccharide-stimulated TNF-α promoter activity by S-adenosylmethionine and 5′-methylthioadenosine 10.1152/ajpgi.00316.2003
The 2009 Human Liver Proteome Project (HLPP) Workshop 26 September 2009, Toronto, Canada 10.1002/pmic.201090074
Methionine adenosyltransferase I/III deficiency: Two Korean compound heterozygous siblings with a novel mutation 10.1023/A:1022829214415
S-adenosylmethionine and methylthioadenosine inhibit cellular FLICE inhibitory protein expression and induce apoptosis in colon cancer cells 10.1124/mol.108.054411
Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect (Oncogene (2009) 28, (781-791) DOI: 10.1038/onc.2008.436) 10.1038/onc.2009.1
Methylthioadenosine phosphorylase gene expression is impaired in human liver cirrhosis and hepatocarcinoma 10.1016/j.bbadis.2004.08.002
Data in support of enhancing metabolomics research through data mining 10.1016/j.dib.2015.02.008
S-Adenosylmethionine Regulates Apurinic/Apyrimidinic Endonuclease 1 Stability: Implication in Hepatocarcinogenesis 10.1053/j.gastro.2008.09.026
Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples 10.1002/prca.200900103
Role of Methionine Adenosyltransferase 2A and S-adenosylmethionine in Mitogen-Induced Growth of Human Colon Cancer Cells 10.1053/j.gastro.2007.03.114
Expression Pattern, Regulation, and Functions of Methionine Adenosyltransferase 2β Splicing Variants in Hepatoma Cells 10.1053/j.gastro.2007.10.027
Identification of a gene-pathway associated with non-alcoholic steatohepatitis 10.1016/j.jhep.2006.10.021
The CBS domain protein MJ0729 of Methanocaldococcus jannaschii is a thermostable protein with a pH-dependent self-oligomerization 10.1021/bi801920r
Methionine adenosyltransferases in liver cancer 10.3748/wjg.v25.i31.4300
S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model 10.1002/hep.22990
S-adenosylmethionine inhibits lipopolysaccharide-induced gene expression via modulation of histone methylation 10.1002/hep.22231
Abnormal Hepatic Methionine and Glutathione Metabolism in Patients with Alcoholic Hepatitis 10.1097/01.ALC.0000108654.77178.03
Purification, crystallization and preliminary X-ray diffraction analysis of the CBS-domain pair from the Methanococcus jannaschii protein MJ0100 10.1107/S1744309108027930
HuR/Methyl-HuR and AUF1 Regulate the MAT Expressed During Liver Proliferation, Differentiation, and Carcinogenesis 10.1053/j.gastro.2010.01.032
Oxidation of specific methionine and tryptophan residues of apolipoprotein A-I in hepatocarcinogenesis 10.1002/pmic.200500070
Synthesis, dihydrofolate reductase inhibition, anti-proliferative testing, and saturation transfer difference 1H-NMR study of some new 2-substituted-4,6-diaminopyrimidine derivatives 10.1248/cpb.60.70
Role of S-adenosyl-L-methionine in liver health and injury 10.1002/hep.21650
Non-alcoholic fatty liver disease proteomics 10.1002/prca.200900119
CD133+ liver cancer stem cells from methionine adenosyl transferase 1A-deficient mice demonstrate resistance to transforming growth factor (TGF)-β-induced apoptosis 10.1002/hep.22743
Proteomics analysis of human nonalcoholic fatty liver 10.1007/978-1-61779-959-4_16
Binding of S-Methyl-5′-Thioadenosine and S-Adenosyl-l-Methionine to Protein MJ0100 Triggers an Open-to-Closed Conformational Change in Its CBS Motif Pair 10.1016/j.jmb.2009.12.012
Impaired liver regeneration in mice lacking glycine N-methyltransferase 10.1002/hep.23033
Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer 10.18632/oncotarget.3191
Leptin's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2β 10.1002/hep.22064
Biomarkers and subtypes of deranged lipid metabolism in nonalcoholic fatty liver disease 10.3748/wjg.v25.i24.3009
Correction: Silencing of human methionine adenosyltransferase 1A expression by methylation of the coding region (Journal of Biological Chemistry (2004)) 10.1074/jbc.A115.410405
SAMe and hur in liver physiology: Usefulness of stem cells in hepatic differentiation research 10.1007/978-1-61779-468-1_12
Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer 10.1016/j.alcohol.2005.03.011
S-Adenosylmethionine revisited: Its essential role in the regulation of liver function 10.1016/S0741-8329(02)00228-8
Methionine metabolism and liver disease 10.1146/annurev.nutr.28.061807.155438
Reciprocal Regulation Between Forkhead Box M1/NF-κB and Methionine Adenosyltransferase 1A Drives Liver Cancer. 10.1002/hep.31196
The L-α-Lysophosphatidylinositol/G Protein-Coupled Receptor 55 System Induces the Development of Nonalcoholic Steatosis and Steatohepatitis. 10.1002/hep.31290
Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly. 10.1016/j.cmet.2020.01.013
SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum. 10.1016/j.isci.2020.101645
PINE: An Automation Tool to Extract and Visualize Protein-Centric Functional Networks. 10.1021/jasms.0c00032
Early treatment efficacy of S-adenosylmethionine in patients with intrahepatic cholestasis: A systematic review. 10.4254/wjh.v12.i2.46
Abnormal concentration of porphyrins in serum from COVID-19 patients. 10.1111/bjh.17060
Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation. 10.3748/wjg.v26.i34.5101
S-adenosyl-L-methionine (SAMe) halts the autoimmune response in patients with primary biliary cholangitis (PBC) via antioxidant and S-glutathionylation processes in cholangiocytes. 10.1016/j.bbadis.2020.165895
Lysine and Arginine Protein Post-translational Modifications by Enhanced DIA Libraries: Quantification in Murine Liver Disease. 10.1021/acs.jproteome.0c00685
1H NMR-Based Urine Metabolomics Reveals Signs of Enhanced Carbon and Nitrogen Recycling in Prostate Cancer. 10.1021/acs.jproteome.0c00091
Metabolic Landscape of the Mouse Liver by Quantitative 31 P Nuclear Magnetic Resonance Analysis of the Phosphorome 10.1002/hep.31676
Aramchol downregulates stearoyl CoA-desaturase 1 in hepatic stellate cells to attenuate cellular fibrogenesis 10.1016/j.jhepr.2021.100237
Anti-miR-518d-5p overcomes liver tumor cell death resistance through mitochondrial activity 10.1038/s41419-021-03827-0
Shelly Lu
Lu Shelly
ORCID: 0000-0003-2128-5407
Current status of hepatocellular carcinoma detection: screening strategies and novel biomarkers 10.1177/1758835919869120
Prohibitin 1 in liver injury and cancer 10.1177/1535370220908257
Chemotherapy-associated liver injury in colorectal cancer 10.1177/1756284820924194
Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation 10.3748/wjg.v26.i34.5101
Hepatocellular Carcinoma: Updates in Pathogenesis, Detection and Treatment 10.3390/cancers12102729
Lysine and Arginine Protein Post-translational Modifications by Enhanced DIA Libraries: Quantification in Murine Liver Disease 10.1021/acs.jproteome.0c00685.s002
Factors Associated With Detection and Survival of T1 Hepatocellular Carcinoma in the United States: National Cancer Database Analysis 10.6004/jnccn.2020.7564
PINE: An Automation Tool to Extract and Visualize Protein-Centric Functional Networks 10.1021/jasms.0c00032
Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly 10.1016/j.cmet.2020.01.013
Reciprocal Regulation Between Forkhead Box M1/NF‐κB and Methionine Adenosyltransferase 1A Drives Liver Cancer 10.1002/hep.31196
Detection of Circulating Tumor Cells and Their Implications as a Biomarker for Diagnosis, Prognostication, and Therapeutic Monitoring in Hepatocellular Carcinoma 10.1002/hep.31165
miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease 10.1016/j.molmet.2019.08.008
Methionine adenosyltransferases in liver cancer 10.3748/wjg.v25.i31.4300
Biomarkers and subtypes of deranged lipid metabolism in non-alcoholic fatty liver disease 10.3748/wjg.v25.i24.3009
Hyaluronan synthase 2–mediated hyaluronan production mediates Notch1 activation and liver fibrosis 10.1126/scitranslmed.aat9284
Methionine Adenosyltransferase α1 Is Targeted to the Mitochondrial Matrix and Interacts with Cytochrome P450 2E1 to Lower Its Expression 10.1002/hep.30762
NOD‐like receptor C4 Inflammasome Regulates the Growth of Colon Cancer Liver Metastasis in NAFLD 10.1002/hep.30693
Prohibitin 1 Acts As a Negative Regulator of Wingless/Integrated‐Beta‐Catenin Signaling in Murine Liver and Human Liver Cancer Cells 10.1002/hep4.1257
The mitochondrial chaperone Prohibitin 1 negatively regulates interleukin-8 in human liver cancers 10.1074/jbc.ra118.004863
MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis 10.1038/s41419-018-1014-y
Liver cancer-associated changes to the proteome: what deserves clinical focus? 10.1080/14789450.2018.1521277
Metabolomic‐based noninvasive serum test to diagnose nonalcoholic steatohepatitis: Results from discovery and validation cohorts 10.1002/hep4.1188
NASH Leading Cause of Liver Transplant in Women: Updated Analysis of Indications For Liver Transplant and Ethnic and Gender Variances 10.1038/s41395-018-0088-6
Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer 10.1053/j.gastro.2018.04.032
Fatty liver in hepatitis C patients post-sustained virological response with direct-acting antivirals 10.3748/wjg.v24.i11.1269
The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury 10.1038/s41467-017-01970-x
Methionine adenosyltransferases in liver health and diseases 10.1016/j.livres.2017.07.002
Role of aramchol in steatohepatitis and fibrosis in mice 10.1002/hep4.1107
Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy 10.1177/1535370217740860
S-adenosylmethionine and methylthioadenosine inhibit cancer metastasis by targeting microRNA 34a/b-methionine adenosyltransferase 2A/2B axis 10.18632/oncotarget.20234
A morphological method for ammonia detection in liver 10.1371/journal.pone.0173914
Coffee Drinking and Alcoholic and Nonalcoholic Fatty Liver Diseases and Viral Hepatitis in the Multiethnic Cohort 10.1016/j.cgh.2017.02.038
Deregulated neddylation in liver fibrosis 10.1002/hep.28933
Prohibitin 1 suppresses liver cancer tumorigenesis in mice and human hepatocellular and cholangiocarcinoma cells 10.1002/hep.28964
Reply to High hepatocellular carcinoma risk among US-born Hispanics 10.1002/cncr.30396
Prohibitin 1 Regulates the H19-Igf2 Axis and Proliferation in Hepatocytes 10.1074/jbc.m116.744045
Prevalence of chronic liver disease and cirrhosis by underlying cause in understudied ethnic groups: The multiethnic cohort 10.1002/hep.28677
MicroRNA-mediated regulation of glutathione and methionine metabolism and its relevance for liver disease 10.1016/j.freeradbiomed.2016.03.021
Deregulated methionine adenosyltransferase α1, c-Myc, and Maf proteins together promote cholangiocarcinoma growth in mice and humans‡ 10.1002/hep.28541
Disparity in liver cancer incidence and chronic liver disease mortality by nativity in Hispanics: The Multiethnic Cohort 10.1002/cncr.29922
Crystallography captures catalytic steps in human methionine adenosyltransferase enzymes 10.1073/pnas.1510959113
Methionine adenosyltransferase α2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells 10.18632/oncotarget.5342
Sex and Ethnic Differences in the Association of Obesity With Risk of Hepatocellular Carcinoma 10.1016/j.cgh.2015.09.015
Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis 10.1016/j.jhep.2015.08.037
Liver receptor homolog 1 and transmethylation fluxes in nonalcoholic steatohepatitis 10.1002/hep.28146
Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1 10.1002/hep.27959
Nonalcoholic fatty liver disease: Update on pathogenesis, diagnosis, treatment and the role of S-adenosylmethionine 10.1177/1535370215579161
Methionine Adenosyltransferase 2B–GIT1 Complex Serves as a Scaffold to Regulate Ras/Raf/MEK1/2 Activity in Human Liver and Colon Cancer Cells 10.1016/j.ajpath.2014.12.016
Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer 10.18632/oncotarget.3191
TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency 10.1038/labinvest.2014.151
S-Adenosylmethionine increases circulating very-low density lipoprotein clearance in non-alcoholic fatty liver disease 10.1016/j.jhep.2014.10.019
S-Adenosylmethionine and Methylthioadenosine Inhibit β-Catenin Signaling by Multiple Mechanisms in Liver and Colon Cancer 10.1124/mol.114.095679
Diabetes and Racial/Ethnic Differences in Hepatocellular Carcinoma Risk: The Multiethnic Cohort 10.1093/jnci/dju326
Association of Coffee Intake With Reduced Incidence of Liver Cancer and Death From Chronic Liver Disease in the US Multiethnic Cohort 10.1053/j.gastro.2014.10.005
Activation of a Novel c-Myc-miR27-Prohibitin 1 Circuitry in Cholestatic Liver Injury Inhibits Glutathione Synthesis in Mice 10.1089/ars.2014.6027
Quantitative proteomic analysis of hepatocyte-secreted extracellular vesicles reveals candidate markers for liver toxicity 10.1016/j.jprot.2014.04.008
GlycineN-methyltransferase expression in the hippocampus and its role in neurogenesis and cognitive performance 10.1002/hipo.22274
S-adenosylmethionine Levels Regulate the Schwann Cell DNA Methylome 10.1016/j.neuron.2014.01.037
Systems biology for hepatologists 10.1002/hep.27023
Molecular mechanisms of lipopolysaccharide-mediated inhibition of glutathione synthesis in mice 10.1016/j.freeradbiomed.2013.11.018
Methionine adenosyltransferase 2B, HuR, and sirtuin 1 protein cross-talk impacts on the effect of resveratrol on apoptosis and growth in liver cancer cells. 10.1074/jbc.a113.487157
Polyamine and methionine adenosyltransferase 2A crosstalk in human colon and liver cancer 10.1016/j.yexcr.2013.04.005
Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis 10.1002/hep.26399
S-adenosylmethionine metabolism and liver disease 10.1016/s1665-2681(19)31355-9
MAT2B-GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer 10.1002/hep.26258
MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma 10.1172/jci63861
Serum UPLC-MS/MS metabolic profiling in an experimental model for acute-liver injury reveals potential biomarkers for hepatotoxicity 10.1007/s11306-011-0329-9
S-adenosylmethionine in Liver Health, Injury, and Cancer 10.1152/physrev.00047.2011
22. Glutathione Synthesis 10.1016/s1874-6047(08)60154-7
Mechanism and Significance of Changes in Glutamate-Cysteine Ligase Expression during Hepatic Fibrogenesis* 10.1074/jbc.m112.370775
Hepatoma Cells From Mice Deficient in Glycine N-Methyltransferase Have Increased RAS Signaling and Activation of Liver Kinase B1 10.1053/j.gastro.2012.05.050
The RNA-Binding Protein Human Antigen R Controls Global Changes in Gene Expression during Schwann Cell Development 10.1523/jneurosci.5868-11.2012
S-adenosyl methionine regulates ubiquitin-conjugating enzyme 9 protein expression and sumoylation in murine liver and human cancers 10.1002/hep.25701
Inhibition of natural killer cells protects the liver against acute injury in the absence of glycine N-methyltransferase 10.1002/hep.25694
Proteomic analysis of human hepatoma cells expressing methionine adenosyltransferase I/III 10.1016/j.jprot.2012.01.009
Effects of S -adenosylmethionine and methylthioadenosine on inflammation-induced colon cancer in mice 10.1093/carcin/bgr295
Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation 10.1002/hep.24795
Where are we in the search for noninvasive nonalcoholic steatohepatitis biomarkers? 10.1002/hep.24642
Methionine adenosyltransferase 1A gene deletion disrupts hepatic very low-density lipoprotein assembly in mice 10.1002/hep.24607
Inhibition of human methionine adenosyltransferase 1A transcription by coding region methylation 10.1002/jcp.22875
High-Frequency Ultrasound Imaging for Longitudinal Evaluation of Non-Alcoholic Fatty Liver Disease Progression in Mice 10.1016/j.ultrasmedbio.2011.04.012
Role of AMP-activated protein kinase in the control of hepatocyte priming and proliferation during liver regeneration 10.1258/ebm.2011.010352
Insulin-like growth factor 1 activates methionine adenosyltransferase 2A transcription by multiple pathways in human colon cancer cells 10.1042/bj20101754
The Hepatocarcinogenic Effect of Methionine and Choline Deficient Diets: An Adaptation to the Warburg Effect? 10.1111/j.1530-0277.2010.01404.x
Role of Methionine Adenosyltransferase Genes in Hepatocarcinogenesis 10.3390/cancers3021480
Sub-proteome approach to the knowledge of liver 10.1002/prca.200900123
S-Adenosylmethionine regulates connexins sub-types expressed by hepatocytes 10.1016/j.ejcb.2010.09.007
Liver-specific deletion of prohibitin 1 results in spontaneous liver injury, fibrosis, and hepatocellular carcinoma in mice 10.1002/hep.23919
Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis 10.1002/hep.23860
Liquid Chromatography−Mass Spectrometry-Based Parallel Metabolic Profiling of Human and Mouse Model Serum Reveals Putative Biomarkers Associated with the Progression of Nonalcoholic Fatty Liver Disease 10.1021/pr1002593
Fatty liver and fibrosis in glycine N-methyltransferase knockout mice is prevented by nicotinamide 10.1002/hep.23639
Epithelial-to-mesenchymal transition of murine liver tumor cells promotes invasion 10.1002/hep.23748
Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples 10.1002/prca.200900103
Novel Function and Intracellular Localization of Methionine Adenosyltransferase 2β Splicing Variants 10.1074/jbc.m109.094821
Forced Expression of Methionine Adenosyltransferase 1A in Human Hepatoma Cells Suppresses in Vivo Tumorigenicity in Mice 10.2353/ajpath.2010.090810
Where are we in the chemoprevention of hepatocellular carcinoma? 10.1002/hep.23497
S-adenosylmethionine regulates dual-specificity mitogen-activated protein kinase phosphatase expression in mouse and human hepatocytes 10.1002/hep.23530
Overview of extracellular microvesicles in drug metabolism 10.1517/17425251003614766
Induction of avian musculoaponeurotic fibrosarcoma proteins by toxic bile acid inhibits expression of glutathione synthetic enzymes and contributes to cholestatic liver injury in mice 10.1002/hep.23471
HuR/Methyl-HuR and AUF1 Regulate the MAT Expressed During Liver Proliferation, Differentiation, and Carcinogenesis 10.1053/j.gastro.2010.01.032
Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation 10.1002/hep.23411
Nonalcoholic Steatohepatitis, Animal Models, and Biomarkers: What Is New? 10.1007/978-1-60327-194-3_6
Impaired liver regeneration in mice lacking glycine N-methyltransferase 10.1002/hep.23033
Identification and characterization of an Nrf2-mediated ARE upstream of the rat glutamate cysteine ligase catalytic subunit gene (GCLC) 10.1002/jcb.22197
S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model 10.1002/hep.22990
Dysregulation of glutathione synthesis during cholestasis in mice: Molecular mechanisms and therapeutic implications 10.1002/hep.22908
S-Adenosylmethionine and Methylthioadenosine Inhibit Cellular FLICE Inhibitory Protein Expression and Induce Apoptosis in Colon Cancer Cells 10.1124/mol.108.054411
Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes 10.1021/pr8004887
Evidence for LKB1/AMP-activated protein kinase/ endothelial nitric oxide synthase cascade regulated by hepatocyte growth factor, S-adenosylmethionine, and nitric oxide in hepatocyte proliferation 10.1002/hep.22660
CD133+ liver cancer stem cells from methionine adenosyl transferase 1A-deficient mice demonstrate resistance to transforming growth factor (TGF)-β-induced apoptosis 10.1002/hep.22743
Switch from Mnt-Max to Myc-Max induces p53 and cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytes 10.1002/hep.22720
Betaine prevents Mallory-Denk body formation in drug-primed mice by epigenetic mechanisms 10.1016/j.yexmp.2008.11.002
Non-alcoholic steatohepatitis and animal models: Understanding the human disease 10.1016/j.biocel.2008.10.027
S-Adenosylmethionine Regulates Apurinic/Apyrimidinic Endonuclease 1 Stability: Implication in Hepatocarcinogenesis 10.1053/j.gastro.2008.09.026
Requirement of RIZ1 for Cancer Prevention by Methyl-Balanced Diet 10.1371/journal.pone.0003390
S-adenosylmethionine and proliferation: new pathways, new targets 10.1042/bst0360848
Antioxidants in the treatment of chronic liver diseases: Why is the efficacy evidence so weak in humans? 10.1002/hep.22463
Changes in S-adenosylmethionine and GSH homeostasis during endotoxemia in mice 10.1038/labinvest.2008.69
Emerging Role of Epigenetics in the Actions of Alcohol 10.1111/j.1530-0277.2008.00729.x
Regulation of glutathione synthesis 10.1016/j.mam.2008.05.005
Alcohol, cofactors and the genetics of hepatocellular carcinoma 10.1111/j.1440-1746.2007.05293.x
S-Adenosylmethionine in cell growth, apoptosis and liver cancer 10.1111/j.1440-1746.2007.05289.x
S-adenosylmethionine inhibits lipopolysaccharide-induced gene expression via modulation of histone methylation 10.1002/hep.22231
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice 10.1002/hep.22159
Epigallocatechin-3-gallate Inhibits Growth of Activated Hepatic Stellate Cells by Enhancing the Capacity of Glutathione Synthesis 10.1124/mol.107.040634
Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice 10.1002/hep.22141
Expression Pattern, Regulation, and Functions of Methionine Adenosyltransferase 2β Splicing Variants in Hepatoma Cells 10.1053/j.gastro.2007.10.027
Leptin's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2β 10.1002/hep.22064
Effects of hepatocyte growth factor on glutathione synthesis, growth, and apoptosis is cell density-dependent 10.1016/j.yexcr.2007.09.015
Role of Methionine Adenosyltransferase 2A and S-adenosylmethionine in Mitogen-Induced Growth of Human Colon Cancer Cells 10.1053/j.gastro.2007.03.114
Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium 10.1093/ajcn/86.1.14
Role of S-adenosyl-L-methionine in liver health and injury 10.1002/hep.21650
Effect of hepatocyte growth factor on methionine adenosyltransferase genes and growth is cell density-dependent in HepG2 cells 10.1002/jcp.20891
Methionine adenosyltransferase and S-adenosylmethionine in alcoholic liver disease 10.1111/j.1440-1746.2006.04575.x
Inhibition of human betaine–homocysteine methyltransferase expression by S-adenosylmethionine and methylthioadenosine 10.1042/bj20061119
S–Adenosylmethionine Regulates Cytoplasmic HuR Via AMP–Activated Kinase 10.1053/j.gastro.2006.04.019
S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity 10.1073/pnas.0509531103
Molecular Profiling of Hepatocellular Carcinoma in Mice with a Chronic Deficiency of Hepatic S-Adenosylmethionine: Relevance in Human Liver Diseases 10.1021/pr050429v.s001
Oxidation of specific methionine and tryptophan residues of apolipoprotein A-I in hepatocarcinogenesis 10.1002/pmic.200500070
Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer 10.1016/j.alcohol.2005.03.011
Tumour necrosis factor α induces co-ordinated activation of rat GSH synthetic enzymes via nuclear factor κB and activator protein-1 10.1042/bj20050795
Nrf1 and Nrf2 Regulate Rat Glutamate-Cysteine Ligase Catalytic Subunit Transcription Indirectly via NF-κB and AP-1 10.1128/mcb.25.14.5933-5946.2005
Cloning and characterization of the human glutathione synthetase 5′-flanking region 10.1042/bj20050439
Homocysteine, the bad thiol 10.1002/hep.20708
Keratin mutation primes mouse liver to oxidative injury 10.1002/hep.20578
Silencing of human methionine adenosyltransferase 1A expression by methylation of the coding region 10.1074/jbc.m410405200
15-Deoxy-Δ12,14-Prostaglandin J2 Protects against Nitrosative PC12 Cell Death through Up-regulation of Intracellular Glutathione Synthesis 10.1074/jbc.m406555200
S-adenosylmethionine and its metabolite induce apoptosis in HepG2 cells: Role of protein phosphatase 1 and Bcl-xS 10.1002/hep.20274
5′-methylthioadenosine modulates the inflammatory response to endotoxin in mice and in rat hepatocytes 10.1002/hep.20154
Impaired liver regeneration in mice lacking methionine adenosyltransferase 1A 10.1096/fj.03-1204fje
Retinoid X Receptor α Regulates Glutathione Homeostasis and Xenobiotic Detoxification Processes in Mouse Liver 10.1124/mol.65.3.550
Abnormal Hepatic Methionine and Glutathione Metabolism in Patients With Alcoholic Hepatitis 10.1097/01.alc.0000108654.77178.03
RXRα-regulated liver SAMe and GSH levels influence susceptibility to alcohol-induced hepatotoxicity 10.1016/s0014-4800(03)00091-1
Induction of Human Methionine Adenosyltransferase 2A Expression by Tumor Necrosis Factor α 10.1074/jbc.m307600200
L-Methionine Availability Regulates Expression of the Methionine Adenosyltransferase 2A Gene in Human Hepatocarcinoma Cells 10.1074/jbc.m211554200
Functional proteomics of nonalcoholic steatohepatitis: Mitochondrial proteins as targets of S-adenosylmethionine 10.1073/pnas.0536625100
Role of S‐adenosylmethionine in two experimental models of pancreatitis 10.1096/fj.01-0752fje
Role of abnormal methionine metabolism in alcoholic liver injury 10.1016/s0741-8329(02)00226-4
Role of AP-1 in the Coordinate Induction of Rat Glutamate-cysteine Ligase and Glutathione Synthetase bytert-Butylhydroquinone 10.1074/jbc.m203812200
Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A 10.1096/fj.02-0078fje
S-adenosylmethionine and methylthioadenosine are antiapoptotic in cultured rat hepatocytes but proapoptotic in human hepatoma cells 10.1053/jhep.2002.30419
S‐Adenosylmethionine: a control switch that regulates liver function 10.1096/fj.01-0401rev
Structure and function study of the complex that synthesizesS-adenosylmethionine 10.1107/s2052252514012585
Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis 10.1053/j.gastro.2017.01.015
Human antigen R contributes to hepatic stellate cell activation and liver fibrosis 10.1002/hep.25828
Non-alcoholic fatty liver disease proteomics 10.1002/prca.200900119
Methionine Metabolism and Liver Disease 10.1146/annurev.nutr.28.061807.155438
Genetic polymorphisms in themethylenetetrahydrofolate reductase andthymidylate synthase genes and risk of hepatocellular carcinoma 10.1002/hep.21735
Identification of a gene-pathway associated with non-alcoholic steatohepatitis 10.1016/j.jhep.2006.10.021
Methylthioadenosine 10.1016/j.biocel.2003.11.016
Jose-Ignacio Riezu-Boj
Riezu-Boj Jose-Ignacio
ORCID: 0000-0002-1885-8457
Inhibition of FOXP3/NFAT interaction enhances T cell function after TCR stimulation 10.4049/jimmunol.1402997
Conventional but not plasmacytoid dendritic cells foster the systemic virus-induced type I IFN response needed for efficient CD8 T cell priming 10.4049/jimmunol.1301440
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Prediction of blood lipid phenotypes using obesity-related genetic polymorphisms and lifestyle data in subjects with excessive body weight 10.1155/2018/4283078
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DNA methylation patterns at sweet taste transducing genes are associated with BMI and carbohydrate intake in an adult population 10.1016/j.appet.2017.09.004
Epigenetic Determinants of Weight Management: Methylation Signatures 10.1007/s13668-015-0140-8
DNA methylation signatures at endoplasmic reticulum stress genes are associated with adiposity and insulin resistance 10.1016/j.ymgme.2017.11.011
Differential lipid metabolism outcomes associated with ADRB2 gene polymorphisms in response to two dietary interventions in overweight/obese subjects 10.1016/j.numecd.2017.11.006
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Differential peripheral blood methylation by α-lipoic acid and EPA supplementation in overweight or obese women during a weight loss program 10.1016/j.jff.2017.07.002
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Dopamine gene methylation patterns are associated with obesity markers and carbohydrate intake 10.1002/brb3.1017
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Association of the Gly482Ser PPARGC1A gene variant with different cholesterol outcomes in response to two energy-restricted diets in subjects with excessive weight 10.1016/j.nut.2017.10.008
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Adherence to Mediterranean diet is associated with methylation changes in inflammation-related genes in peripheral blood cells 10.1007/s13105-017-0552-6
HUMAN HERPESVIRUS 6 IN SPAIN - SEROPREVALENCE IN BLOOD-DONORS AND PATIENTS WITH LYMPHOPROLIFERATIVE DISORDERS OR HIV-INFECTION 10.1111/j.1423-0410.1991.tb00874.x
Changes in Anxiety and Depression Traits Induced by Energy Restriction: Predictive Value of the Baseline Status 10.3390/nu11061206
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Insulin Sensitivity Is Associated with Lipoprotein Lipase (LPL) and Catenin Delta 2 (CTNND2) DNA Methylation in Peripheral White Blood Cells in Non-Diabetic Young Women 10.3390/ijms20122928
Endoplasmic reticulum stress epigenetics is related to adiposity, dyslipidemia, and insulin resistance 10.1080/21623945.2018.1447731
Associations between olfactory pathway gene methylation marks, obesity features and dietary intakes 10.1186/s12263-019-0635-9
Models Integrating Genetic and Lifestyle Interactions on Two Adiposity Phenotypes for Personalized Prescription of Energy-Restricted Diets With Different Macronutrient Distribution 10.3389/fgene.2019.00686
Interaction Among Sex, Aging, and Epigenetic Processes Concerning Visceral Fat, Insulin Resistance, and Dyslipidaemia. 10.3389/fendo.2019.00496
Genetic and nongenetic factors explaining metabolically healthy and unhealthy phenotypes in participants with excessive adiposity: relevance for personalized nutrition. 10.1177/2042018819877303
Interplay of an Obesity-Based Genetic Risk Score with Dietary and Endocrine Factors on Insulin Resistance 10.3390/nu12010033
Circulating adiposity‐related microRNAs as predictors of the response to a low‐fat diet in subjects with obesity 10.1111/jcmm.14920
Association of the SH2B1 rs7359397 Gene Polymorphism with Steatosis Severity in Subjects with Obesity and Non-Alcoholic Fatty Liver Disease 10.3390/nu12051260
Sex-Specific Associations between Gut Prevotellaceae and Host Genetics on Adiposity 10.3390/microorganisms8060938
PPARGC1A Gene Promoter Methylation as a Biomarker of Insulin Secretion and Sensitivity in Response to Glucose Challenges 10.3390/nu12092790
Comprehensive Analysis Reveals Novel Interactions between Circulating MicroRNAs and Gut Microbiota Composition in Human Obesity 10.3390/ijms21249509
Differentially methylated regions (DMRs) in PON3 gene between responders and non-responders to a weight loss dietary intervention: a new tool for precision management of obesity 10.1080/15592294.2021.1873629
Differential response to a 6-month energy-restricted treatment depending on SH2B1 rs7359397 variant in NAFLD subjects: Fatty Liver in Obesity (FLiO) Study 10.1007/s00394-020-02476-x
Gut Microbiota Bacterial Species Associated with Mediterranean Diet-Related Food Groups in a Northern Spanish Population 10.3390/nu13020636
Diet- and sex-related changes of gut microbiota composition and functional profiles after 4 months of weight loss intervention 10.1007/s00394-021-02508-0
Three Different Genetic Risk Scores Based on Fatty Liver Index, Magnetic Resonance Imaging and Lipidomic for a Nutrigenetic Personalized Management of NAFLD: The Fatty Liver in Obesity Study 10.3390/diagnostics11061083
A predictive regression model of the obesity-related inflammatory status based on gut microbiota composition 10.1038/s41366-021-00904-4
Gut Microbiota Differences According to Ultra-Processed Food Consumption in a Spanish Population 10.3390/nu13082710
Javier Munoz
Munoz Javier
ORCID: 0000-0003-3288-3496
CD24 tracks divergent pluripotent states in mouse and human cells 10.1038/ncomms8329
DAZL regulates Tet1 translation in murine embryonic stem cells 10.15252/embr.201540538
Rb and FZR1/Cdh1 determine CDK4/6-cyclin D requirement in C. elegans and human cancer cells 10.1038/ncomms6906
Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2 10.1101/gad.249748.114
A synthetic lethal interaction between APC/C and topoisomerase poisons uncovered by proteomic screens 10.1016/j.celrep.2014.01.017
DAZL Limits Pluripotency, Differentiation, and Apoptosis in Developing Primordial Germ Cells 10.1016/j.stemcr.2014.09.003
From the Human Genome to the Human Proteome 10.1002/anie.201406545
Genome-wide characterization of the routes to pluripotency 10.1038/nature14046
Proteome adaptation in cell reprogramming proceeds via distinct transcriptional networks 10.1038/ncomms6613
Small RNA changes en route to distinct cellular states of induced pluripotency 10.1038/ncomms6522
A proteomic characterization of factors enriched at nascent DNA molecules 10.1016/j.celrep.2013.03.009
F-actin asymmetry and the endoplasmic reticulum-associated TCC-1 protein contribute to stereotypic spindle movements in the Caenorhabditis elegans embryo 10.1091/mbc.E13-02-0076
Finding the same needles in the haystack? A comparison of phosphotyrosine peptides enriched by immuno-affinity precipitation and metal-based affinity chromatography 10.1016/j.jprot.2013.07.024
Integrative analysis of miRNA and mRNA expression profiles in pheochromocytoma and paraganglioma identifies genotype-specific markers and potentially regulated pathways 10.1530/ERC-12-0183
Next-generation proteomics: towards an integrative view of proteome dynamics 10.1038/nrg3356
Role of mass spectrometry-based proteomics in the study of cellular reprogramming and induced pluripotent stem cells 10.1586/EPR.12.30
Targeted analysis of tyrosine phosphorylation by immuno-affinity enrichment of tyrosine phosphorylated peptides prior to mass spectrometric analysis 10.1016/j.ymeth.2011.09.003
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers 10.1038/emboj.2012.166
aPKC phosphorylates NuMA-related LIN-5 to position the mitotic spindle during asymmetric division 10.1038/ncb2315
Deconvolution of overlapping isotopic clusters improves quantification of stable isotope-labeled peptides 10.1016/j.jprot.2011.04.022
Investigating the role of FGF-2 in stem cell maintenance by global phosphoproteomics profiling 10.1002/pmic.201100048
Quantitative proteome and phosphoproteome analysis of human pluripotent stem cells 10.1007/978-1-61779-201-4_22
RockerBox: analysis and filtering of massive proteomics search results 10.1021/pr1010185
The quantitative proteomes of human-induced pluripotent stem cells and embryonic stem cells 10.1038/msb.2011.84
Perspectives in stem cell proteomics 10.1186/gm45
Phosphorylation dynamics during early differentiation of human embryonic stem cells 10.1016/j.stem.2009.05.021
Regulation of stathmin phosphorylation in mouse liver progenitor-29 cells during proteasome inhibition 10.1002/pmic.200900110
Snapshots of kinase activities 10.1038/nbt1009-912
Mass spectrometric characterization of mitochondrial complex I NDUFA10 variants 10.1002/pmic.200701085
Redox regulation of methylthioadenosine phosphorylase in liver cells: molecular mechanism and functional implications 10.1042/BJ20071569
Toward the discovery of new biomarkers of hepatocellular carcinoma by proteomics 10.1111/j.1478-3231.2007.01447.x
Methylthioadenosine reverses brain autoimmune disease 10.1002/ana.20895
Molecular profiling of hepatocellular carcinoma in mice with a chronic deficiency of hepatic s-adenosylmethionine: relevance in human liver diseases 10.1021/pr050429v
Oxidation of specific methionine and tryptophan residues of apolipoprotein A-I in hepatocarcinogenesis 10.1002/pmic.200500070
Multisite Phosphorylation of NuMA-Related LIN-5 Controls Mitotic Spindle Positioning in C. elegans 10.1371/journal.pgen.1006291
USP7 is a SUMO deubiquitinase essential for DNA replication 10.1038/nsmb.3185
On the Statistical Significance of Compressed Ratios in Isobaric Labeling: A Cross-Platform Comparison 10.1021/acs.jproteome.6b00151
Targeting Tumor Mitochondrial Metabolism Overcomes Resistance to Antiangiogenics 10.1016/j.celrep.2016.05.052
A tissue-specific protein purification approach in Caenorhabditis elegans identifies novel interaction partners of DLG-1/Discs large 10.1186/s12915-016-0286-x
Fluctuations in histone H4 isoforms during cellular reprogramming monitored by middle-down proteomics 10.1002/pmic.201500031
Urea Artifacts Interfere with Immuno-Purification of Lysine Acetylation 10.1021/acs.jproteome.6b00463
Evolution of Yin and Yang isoforms of a chromatin remodeling subunit precedes the creation of two genes 10.7554/eLife.48119
Platelet factor 4 is a biomarker for lymphatic-promoted disorders 10.1172/jci.insight.135109
Frequent mutations in the amino-terminal domain of BCL7A impair its tumor suppressor role in DLBCL 10.1038/s41375-020-0919-5
Induction of Lysosome Membrane Permeabilization as a Therapeutic Strategy to Target Pancreatic Cancer Stem Cells 10.3390/cancers12071790
Dissection of two routes to naïve pluripotency using different kinase inhibitors 10.1038/s41467-021-22181-5
USP7 limits CDK1 activity throughout the cell cycle 10.15252/embj.201899692
PrimPol‐mediated repriming facilitates replication traverse of DNA interstrand crosslinks 10.15252/embj.2020106355
KRAS4A induces metastatic lung adenocarcinomas in vivo in the absence of the KRAS4B isoform 10.1073/pnas.2023112118
A drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent local relapse and treat established brain metastasis. 10.1101/2020.10.16.329243
In vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer 10.1038/s41467-018-05742-z
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STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis article 10.1038/s41591-018-0044-4
Proteomic analysis of liver diseases: Molecular mechanisms biomarker discovery 10.2174/138955708783331595
p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors 10.1016/j.ccell.2018.11.008
Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state 10.1038/s41591-020-1073-3
PrimPol primase mediates replication traverse of DNA interstrand crosslinks 10.1101/2020.05.19.104729
Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3 10.1016/j.celrep.2019.05.095
Erratum: Genome-wide characterization of the routes to pluripotency (Nature (2014) 516 (198-206) DOI: 10.1038/nature14046) 10.1038/nature14606
Inactivation of EMILIN-1 by proteolysis and secretion in small extracellular vesicles favors melanoma progression and metastasis 10.1101/2021.06.02.446715
Hsa-miR-139-5p is a prognostic thyroid cancer marker involved in HNRNPF-mediated alternative splicing 10.1002/ijc.32622
Postlymphadenectomy Analysis of Exosomes from Lymphatic Exudate/Exudative Seroma of Melanoma Patients 10.1007/978-1-0716-1205-7_25
Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1 10.1038/s41467-017-02353-y
Use of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and BRAFV600E mutation 10.1084/jem.20181522
A cell cycle kinase-phosphatase module restrains PI3KAkt activity in an mTORC1-dependent manner 10.1101/2020.11.26.399915
Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling 10.1038/s41467-021-23857-8
Inactivation of emilin-1 by proteolysis and secretion in small extracellular vesicles favors melanoma progression and metastasis 10.3390/ijms22147406
The molecular pathogenesis of the NUP98-HOXA9 fusion protein in acute myeloid leukemia 10.1038/leu.2017.194
Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases 10.1038/s41556-020-0573-1
A multicentric study to evaluate the use of relative retention times in targeted proteomics 10.1016/j.jprot.2016.10.014
Thrombocytopenia-associated mutations in Ser/Thr kinase MASTL deregulate actin cytoskeletal dynamics in platelets 10.1172/JCI121876
Proteotyping pluripotency with mass spectrometry 10.1080/14789450.2019.1604229
Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine 10.1038/nature22977
A proteomic approach for systematic mapping of substrates of human deubiquitinating enzymes 10.3390/ijms22094851
In-depth proteomic characterization of classical and non-classical monocyte subsets 10.3390/proteomes6010008
CUL4A contributes to the biology of basal-like breast tumors through modulation of cell growth and antitumor immune response 10.18632/oncotarget.1915
Antimetastatic dsRNA mimics identified by live imaging of pathogenic neolymphangiogenesis 10.1101/2019.12.26.887943
Exosomes are key regulators of non-cell autonomous communication in senescence 10.1101/356238
Generalized displacement of DNA- And RNA-binding factors mediates the toxicity of arginine-rich cell-penetrating peptides 10.1101/441808
MTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer 10.1038/nature22964
The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity 10.1016/j.celrep.2017.12.062
Wnt-mediated interactions of tumor-initiating cells with a macrophage niche drive skin tumor formation 10.1101/2020.07.17.209338
Erratum to: STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis (Nature Medicine, (2018), 24, 7, (1024-1035), 10.1038/s41591-018-0044-4) 10.1038/s41591-018-0108-5
Atherosclerotic pre-conditioning affects the paracrine role of circulating angiogenic cells ex-vivo 10.3390/ijms21155256
MATIAS AVILA
AVILA MATIAS
ORCID: 0000-0001-6570-3557
5′-Methylthioadenosine Modulates the Inflammatory Response to Endotoxin in Mice and in Rat Hepatocytes 10.1002/hep.20154
Altered processing of precursor transcripts and increased levels of the subunit I of mitochondrial cytochrome c oxidase in Syrian hamster fetal cells initiated with ionizing radiation 10.1093/carcin/18.8.1569
An inositol phosphoglycan stimulates glycolysis in human platelets 10.1016/S0006-291X(05)81171-4
Messenger RNA therapy for rare genetic metabolic diseases 10.1136/gutjnl-2019-318269
Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease 10.18632/oncotarget.10246
The EGFR signalling system in the liver: From hepatoprotection to hepatocarcinogenesis 10.1007/s00535-013-0907-x
Engineered fibroblast growth factor 19 protects from acetaminophen-induced liver injury and stimulates aged liver regeneration in mice 10.1038/cddis.2017.480
Amphiregulin: A new growth factor in hepatocarcinogenesis 10.1016/j.canlet.2007.01.015
Insulin-like effects of inositol phosphate-glycan on messenger RNA expression in rat hepatocytes 10.1210/mend-5-8-1062
Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies 10.1038/ncomms15424
The anticoagulant rivaroxaban lowers portal hypertension in cirrhotic rats mainly by deactivating hepatic stellate cells 10.1002/hep.29084
Epidermal growth factor receptor (EGFR) crosstalks in liver cancer 10.3390/cancers3022444
Amphiregulin Induces the Alternative Splicing of p73 Into Its Oncogenic Isoform ΔEx2p73 in Human Hepatocellular Tumors 10.1053/j.gastro.2009.07.065
Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis 10.1038/s41467-019-11004-3
X-box Binding Protein 1 Regulates Unfolded Protein, Acute-Phase, and DNA Damage Responses During Regeneration of Mouse Liver 10.1053/j.gastro.2016.12.040
Inflammation and liver cancer: New molecular links 10.1111/j.1749-6632.2009.03704.x
SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer 10.1016/j.ebiom.2018.12.031
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Oral Methylthioadenosine Administration Attenuates Fibrosis and Chronic Liver Disease Progression in Mdr2-/- Mice 10.1371/journal.pone.0015690
Glycosyl-phosphatidyl inositol-phospholipase type D: A possible candidate for the generation of second messengers 10.1006/bbrc.1997.6475
Connective tissue growth factor autocriny in human hepatocellular carcinoma: Oncogenic role and regulation by epidermal growth factor receptor/yes-associated protein-mediated activation 10.1002/hep.24587
Methylthioadenosine 10.1016/j.biocel.2003.11.016
Making sorafenib irresistible: In vivo screening for mechanisms of therapy resistance in hepatocellular carcinoma hits on Mapk14 10.1002/hep.27739
Up-regulation of the anti-inflammatory adipokine adiponectin in acute liver failure in mice 10.1016/j.jhep.2005.08.019
Erratum: A phospho-oligosaccharide can reproduce the stimulatory effect of insulin on glycolytic flux in human fibroblasts (Biochemical and Biophysical Research Communications, Volume 166, Number 2, January 30, 1990, pages 765-771) 10.1016/0006-291X(90)92404-N
Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF 10.1126/scisignal.2001936
Fibroblast growth factor 15/19 (FGF15/19) protects from diet-induced hepatic steatosis: Development of an FGF19-based chimeric molecule to promote fatty liver regeneration 10.1136/gutjnl-2016-312975
Functional expression of human poly(ADP‐ribose) polymerase in Schizosaccharomyces pombe results in mitotic delay at G1, increased mutation rate, and sensitization to radiation 10.1002/yea.320100803
Chromatin dynamics during liver regeneration 10.1016/j.semcdb.2019.03.004
Toll-like receptor-4 expression by hepatic progenitor cells and biliary epithelial cells in HCV-related chronic liver disease 10.1038/modpathol.2011.197
Molecular profiling of hepatocellular carcinoma in mice with a chronic deficiency of hepatic S-adenosylmethionine: Relevance in human liver diseases 10.1021/pr050429v
S-adenosylmethionine and methylthioadenosine are antiapoptotic in cultured rat hepatocytes but proapoptotic in human hepatoma cells 10.1053/jhep.2002.30419
Current and innovative emerging therapies for porphyrias with hepatic involvement 10.1016/j.jhep.2019.05.003
Transcription of the MAT2A gene, coding for methionine adenosyltransferase, is up-regulated by E2F and Sp1 at a chromatin level during proliferation of liver cells 10.1016/j.biocel.2007.01.009
LKB1: Controlling Quiescence and Genomic Integrity at Home 10.1016/j.tem.2018.03.017
Regulation of hepatocyte identity and quiescence 10.1007/s00018-015-1970-7
Overexpression of the transcription factor MEF2D in hepatocellular carcinoma sustains malignant character by suppressing G2-M transition genes 10.1158/0008-5472.CAN-13-2171
Methylthioadenosine reverses brain autoimmune disease 10.1002/ana.20895
Functional proteomics of nonalcoholic steatohepatitis: Mitochondrial proteins as targets of S-adenosylmethionine 10.1073/pnas.0536625100
Amphiregulin contributes to the transformed phenotype of human hepatocellular carcinoma cells 10.1158/0008-5472.CAN-06-0404
Differential regulation of the JNK/AP-1 pathway by S-adenosylmethionine and methylthioadenosine in primary rat hepatocytes versus HuH7 hepatoma cells 10.1152/ajpgi.00282.2005
The product of the cph oncogene is a truncated, nucleotide-binding protein that enhances cellular survival to stress 10.1038/sj.onc.1202324
MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis 10.1038/s41419-018-1014-y
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Prioritizing Popular Proteins in Liver Cancer: Remodelling One-Carbon Metabolism 10.1021/acs.jproteome.7b00390
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Deciphering liver zonation: New insights into the β-catenin, Tcf4, and HNF4α triad 10.1002/hep.27000
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The Epidermal Growth Factor Receptor Ligand Amphiregulin Protects From Cholestatic Liver Injury and Regulates Bile Acids Synthesis 10.1002/hep.30348
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Increased manganese superoxide dismutase activity, protein, and mRNA levels and concurrent induction of tumor necrosis factor alpha in radiation-initiated Syrian hamster cells 10.1002/(SICI)1098-2744(199612)17:4
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Hyperhomocysteinemia in liver cirrhosis mechanisms and role in vascular and hepatic fibrosis 10.1161/HY1101.099499
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TREATMENT WITH GLUCOCORTICOIDS INTERFERES WITH BILE ACID HOMEOSTASIS BY AFFECTING FXR/FGF19-MEDIATED ILEUM-LIVER CROSSTALK 10.1016/S0168-8278(16)00108-2
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Novel role of amphiregulin in bile acids metabolism and protection from cholestatic liver injury 10.1016/S0168-8278(18)30369-6
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Impaired liver regeneration in mice lacking methionine adenosyltransferase 1A 10.1096/FJ.03-1204FJE
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Sumoylation/acetylation drives forward oncogenic role of LKB1 in Liver 10.1016/S0618-8278(19)30724-8
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The Switch: Mechanisms Governing Macrophage Phenotypic Variability in Liver Disease 10.1007/978-3-319-58106-4_4
Wnt/beta-catenin activation and macrophage induction during liver cancer development following steatosis 10.1038/ONC.2017.207
Hepatic Mitochondrial DNA/Toll-Like Receptor 9/MicroRNA-223 Forms a Negative Feedback Loop to Limit Neutrophil Overactivation and Acetaminophen Hepatotoxicity in Mice 10.1002/HEP.29153
Characteristics of the specific humoral response in patients with advanced solid tumors after active immunotherapy with a VEGF vaccine, at different antigen doses and using two distinct adjuvants 10.1186/S12865-017-0222-Z
Serum metabolites as diagnostic biomarkers for cholangiocarcinoma, hepatocellular carcinoma and primary sclerosing cholangitis 10.1016/S0618-8278(19)31642-1
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Ischaemia reperfusion injury in liver transplantation: Cellular and molecular mechanisms 10.1111/LIV.14091
SLU7 controls genome integrity: New role of truncated SRSF3 proteins 10.1016/S0618-8278(19)30715-7
Identification of new epigenetic targets in hepatic fibrosis 10.1016/S0618-8278(19)30345-7
Overexpression of c-Jun N-terminal Kinase-1 coincides with the acquisition of cholangiocytic markers in experimental cholangiocarcinoma 10.1016/S0618-8278(19)31163-6
Dual targeting of G9a and DNM-methyltransferase-1 for the treatment of experimental cholangiocarcinoma 10.1016/S0618-8278(19)30049-0
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Loss of c‐Jun N‐terminal Kinase 1 and 2 Function in Liver Epithelial Cells Triggers Biliary Hyperproliferation Resembling Cholangiocarcinoma 10.1002/hep4.1495
A Novel Serum Metabolomic Profile for the Differential Diagnosis of Distal Cholangiocarcinoma and Pancreatic Ductal Adenocarcinoma 10.3390/cancers12061433
Pilot Multi-Omic Analysis of Human Bile from Benign and Malignant Biliary Strictures: A Machine-Learning Approach 10.3390/cancers12061644
Amphiregulin Aggravates Glomerulonephritis via Recruitment and Activation of Myeloid Cells 10.1681/ASN.2019111215
Epigenetic Mechanisms in Gastric Cancer: Potential New Therapeutic Opportunities 10.3390/ijms21155500
Epigenetics in hepatocellular carcinoma development and therapy: The tip of the iceberg 10.1016/j.jhepr.2020.100167
Vitamin A in Nonalcoholic Fatty Liver Disease: A Key Player in an Offside Position? 10.1016/j.jcmgh.2020.08.007
Hepatocellular Carcinoma: Updates in Pathogenesis, Detection and Treatment 10.3390/cancers12102729
Epigenetics in Liver Fibrosis: Could HDACs be a Therapeutic Target? 10.3390/cells9102321
Multi-Omics Integration Highlights the Role of Ubiquitination in CCl4-Induced Liver Fibrosis 10.3390/ijms21239043
Dual Pharmacological Targeting of HDACs and PDE5 Inhibits Liver Disease Progression in a Mouse Model of Biliary Inflammation and Fibrosis 10.3390/cancers12123748
Abnormal Liver Function Test in Patients Infected with Coronavirus (SARS-CoV-2): A Retrospective Single-Center Study from Spain 10.3390/jcm10051039
ARMCX3 Mediates Susceptibility to Hepatic Tumorigenesis Promoted by Dietary Lipotoxicity 10.3390/cancers13051110
Epigenetic Biomarkers for the Diagnosis and Treatment of Liver Disease 10.3390/cancers13061265
Fibrotic Events in the Progression of Cholestatic Liver Disease 10.3390/cells10051107
The TGF-β Pathway: A Pharmacological Target in Hepatocellular Carcinoma? 10.3390/cancers13133248
Summary of the Sussex-Huawei locomotion-transportation recognition challenge
Observation of a manifold in the chaotic phase space of an asymmetric optical microcavity
Localized temporal variation of Earth's inner-core boundary from high-quality waveform doublets
Off-axis multi-wavelength dispersion controlling metalens for multi-color imaging
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